Reductive Charge Transfer through an RNA Aptamer
نویسندگان
چکیده
منابع مشابه
An RNA aptamer that induces transcription.
We identified an RNA aptamer that induces TetR-controlled gene expression in Escherichia coli when expressed in the cell. The aptamer was found by a combined approach of in vitro selection for TetR binding and in vivo screening for TetR induction. The smallest active aptamer folds into a stem-loop with an internal loop interrupting the stem. Mutational analysis in vivo and in-line probing in vi...
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Aptamers are nucleic acid molecules selected in vitro to bind small molecules, peptides, proteins or even other nucleic acids with high affinity and specificity. They offer a unique opportunity to extend our knowledge on the basic principles of nucleic acid architecture and ligand recognition. Despite their probable absence in organisms, RNA aptamers are likely to play an important role in mole...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2020
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.202009430